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In all cases the drugs were given orally through a stomach tube and zyloprim. Saccades can be voluntary Hallett, 1978 ; or can at other times occur automatically without any conscious effort, such as during the normal process of reading or during the resetting of the eye position in optokinetic nystagmus. Fast phases of nystagmus are thought to be structurally very similar to saccades and show similar amplitude and velocity characteristics Ron et al., 1972 ; . Fast phases of nystagmus which are artificially induced, for example by caloric irrigation, show longer durations. It is also shown by Ron et al., 1972 ; that alertness influences the duration of saccades with longer durations found for lower levels of alertness. The size of the smallest saccade is about 3 minutes arc Haddad et al., 1973 ; and the largest possible is about 90. The acceleration of the eye is large as high as 40, 000 second2 for a 10 amplitude saccade. Peak velocity is reached roughly one third of the way through a saccade, followed by gradual deceleration. The eye comes quickly to rest at the end of a saccade in order to allow the eye to focus on the new scene. The eye is slowed down by the momentary activation of the antagonist muscles Robinson, 1981 ; . Saccades normally fall short of a target, even for small saccades, by roughly 10% of the amplitude of the target jump. A corrective saccade normally makes up the remaining 10% of the distance required to reach the target and occurs with a shorter latency than the initial saccade Prablanc, 1974 ; . The corrective saccade has a latency of about 130 ms considerably shorter than the primary saccade latency ; . It is thought that the saccadic system can sense either before, or just after, the first saccade, that it is too small and initiate the corrective saccade with reduced latency. Prablanc et al. 1974 ; investigated the occurrence of saccades in response to the sudden illumination of a light source. They found that corrective saccades did not occur if the light was extinguished during the period of the first saccade. Corrective saccades with the usual short latency occur if the light is re-illuminated before the end of the initial saccade, but only if the light is within about 4 of its original position. Saccades with a longer latency occur if a light is illuminated further than 4 from the original light position. It seems that when the target is moved by greater than 4 the full saccadic process must start again because the position of the target differs significantly from that expected by the saccadic system. During repetitive, predictable target jumps the saccadic system is able to move with minimal, or zero, latency to the target Robinson, 1981, for instance, herbs for impotence. Awe, E. Oa; Makinde, J. M.b; Olajide, O. Ab; Wahkeel, O .Ka; Adeloye, A. O. Department of Pharmacology and Therapeutics, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, bDepartment of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, cDepartment of Chemistry, Obafemi Awolowo University Ile-Ife, Nigeria. E-mail: awemman yahoo and accupril.

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