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Botstein, P. 1993 ; Is QT interval prolongation harmful? A regulatory perspective. American Journal of Cardiology, 72, 50B52B. Committee for Proprietary Medicinal Products 1997 ; Points to Consider: The Assessment of the Potential for QT Interval Prolongation by Non-Cardiovascular Medicinal Products. London: European Agency for the Evaluation of Medicinal Products. : emea .int pdfs human swp 098696en Diaz, F. J. & de Leon, J. 2002 ; Excessive antipsychotic dosing in two US state hospitals. Journal of Clinical Psychiatry, 63, 9981003. Funk-Brentano, C. & Jaillon, P. 1993 ; Rate-corrected QT interval: techniques and limitations. American Journal of Cardiology, 72, 17B22B. Ganguly, R., Kotzan, J. A., Miller, L. S., et al 2004 ; Prevalence, trends, and factors associated with antipsychotic polypharmacy among Medicaid-eligible schizophrenia patients, 19982000. Journal of Clinical Psychiatry, 65, 13771388. Garson, A. 1993 ; How to measure the QT interval what is normal? American Journal of Cardiology, 72, 14B16B. Glassman, A. H. & Bigger, Jr., J. T. 2001 ; Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. American Journal of Psychiatry, 158, 17741782. Griffiths, C. & Flanagan, R. J. 2005 ; Fatal poisoning with antipsychotic drugs, England and Wales 19932002. Psychopharmacology, 19, 667674. Harrington, M., Lelliott, P., Paton, C., et al 2002 ; The results of a multi-centre audit of the prescribing of antipsychotic drugs for in-patients in the UK. Psychiatric Bulletin, 26, 414418. Hatta, K., Takahashi, T., Nakamura, H., et al 1999 ; Hypokalemia and agitation in acute psychotic patients. Psychiatric Resource, 86, 8588. Haw, C. & Stubbs, J. 2003 ; Combined antipsychotics for `difficult-to-manage' and forensic patients with schizophrenia: reasons for prescribing and perceived benefits. Psychiatric Bulletin, 27, 449452. Hennessy, S., Bilker, W. B., Knauss, J. S., et al 2002 ; Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data. BMJ, 325, 10701072. Ito, H., Koyama, A. & Higuchi, T. 2005 ; Polypharmacy and excessive dosing: psychiatrists' perceptions of antipsychotic drug prescription. British Journal of Psychiatry, 187, 243 247. Jusic, N. & Lader, M. 1994 ; Post-mortem antipsychotic drug concentrations and unexplained deaths. British Journal of Psychiatry, 165, 787791. Kupfer, D. & Sartorius, N. 2002 ; The usefulness and use of second-generation antipsychotic medications. Current Opinion in Psychiatry, 15 suppl. 1 ; , S1S30. Labellarte, M. J., Crosson, J. E. & Riddle, M. A. 2003 ; The relevance of prolonged QTC measurement to pediatric psychopharmacology. Journal of the American Academy of Child and Adolescent Psychiatry, 42, 642650. Lelliott, P., Paton, C., Harrington, M., et al 2002 ; The influence of patient variables on polypharmacy and combined high dose of antipsychotic drugs prescribed for in-patients. Psychiatric Bulletin, 26, 411414. Liperoti, R., Gambassi, G., Lapane, K. L., et al 2005 ; Conventional and atypical antipsychotics and the risk of hospitalization for ventricular arrhythmias or cardiac arrest. Archives of Internal Medicine, 165, 696701. Malik, M. & Camm, A. J. 2001 ; Evaluation of drug-induced QT interval prolongation. Drug Safety, 24, 323351. Marder, S. R., Essock, S. M., Miller, A. L., et al 2004 ; Physical health monitoring of patients with schizophrenia. American Journal of Psychiatry, 161, 13341349. McAllister-Williams, R. H. & Ferrier, I. N. 2002 ; Rapid tranquillisation: time for a reappraisal of options for parenteral therapy. British Journal of Psychiatry, 180, 485489. Medicines Control Agency & Committee on Safety of Medicines 2001 ; QT interval prolongation with antipsychotics. Current Problems in Pharmacovigilance, 27, 4. Treatment of eczema with Cardiospermum halicacabum. Cardiospermum ointment and ointment base in part-placebo comparison - a controlled trial ; Summary In a prospective, double blind trial, controlled by part placebo comparison, 28 patients with various forms of eczema were treated with Cardiospermum ointment Halicar , DHU Karlsruhe ; and ointment base for 3 weeks. At the beginning, during the course and after treatment, ten objective and subjective symptoms desquamation, dryness, pruritus, infiltration, erosion excoriation, fissures rhagades, lichenification, edema, vesicles, and erythema ; were recorded by means of a verbal rating scale and from the corresponding values a total score was calculated. The results of the therapeutic measures were evaluated by means of the decrease of the total score. Referring to all parameters Cardiospermum ointment proved to be significantly superior to the ointment base. Tolerability was judged to be predominately well or very well. Keywords Cardiospermum halicacabum, Halicar , Cardiospermum ointment, eczema, clinical trial Autor[ Mihai-Alin Scarlat, Mircea Tama J[ 27.3 Z. Phytother. 27, Nr. 3, 120-121 2006 ; Vorlufige Ergebnisse einer klinischen Studie ber die Wirkung von Rosmarini folium pulvis 2 x 0, 5 zur Behandlung arterieller Hypotonie Preliminary results of a clinical trial with Rosmarini folium pulvis 2 x 0, 5 the treatment of chronic low blood pressure ; Zusammenfassung Rosmarin wird in der Fachliteratur unter anderem als Mittel zur Steigerung des arteriellen Blutdrucks bei Patienten mit chronischer Hypotonie genannt. Wir haben uns daher zum Ziel gesetzt, eine standardisierte pharmazeutische Zubereitung aus Rosmarin herzustellen und diese klinisch auf ihre Wirksamkeit bei Patienten mit chronischer Hypotonie zu testen. Die Untersuchungen erfolgten mit Rosmarin-Herknften, die in Cluj-Napoca Rumnien ; beheimatet sind. Schlsselwrter Rosmarinus officinalis L., Hypotonie, klinische Studie Summary In medical literature, Rosemary is noted to efficiently increase blood pressure in chronic low blood pressure patients. Our goal was to create a set of standardized pharmaceutical products made from Rosemary, which were subjected to preliminary clinical testing in order to prove their therapeutic efficacy in chronic low blood pressure. Species of rosemary found in ClujNapoca Romania ; were used during the trial. Key words Rosmarinus officinalis L., hypotension, clinical trial Autor[ Moerman, D.E. J[ 18.1 Zeitschrift f. Phytother. 18, Nr. 1, 20-23 1997 ; Heilpflanzen aus Nordamerika Medicinal plants from North America ; Summary Native American people developed a sophisticated plant-based medical system in the tenth milennia before the European conquest of America. Many of the plants they used are famillar medicinal species, and have taken a role in moderne clinal treatments. 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As discussed above, information is gleaned from pharmaceutical manufacturer dossiers, published research, FDA analyses published on its Web site and possibly modeling and analysis done by the health plan itself. Pharmacy staff normally conducts a search for relevant primary literature using MEDLINE and possibly other databases. Secondary sources such as Cochrane reviews may also be consulted. Summaries of the information from these sources, and sometimes research articles themselves, are distributed to P&T committee member prior to a meeting. The homework for one of these meetings is substantial. P&T committees we have seen are comprised of primarily physicians and pharmacists. One study reported a mix of 63 percent physicians, 32 percent pharmacists and the rest other.23 We saw one committee with a majority of physicians 71 percent ; , and the rest had less than 50 percent. Pharmacists comprised most of the rest of the committee members. These committees ranged in size from 11 to 25 people. Other members included a psychologist, osteopaths, registered nurses and employer representatives. Two of the committees explicitly noted that only members not employed directly by the health plan were allowed to vote on formulary decisions. The pharmacy benefit manager PBM ; committee profiled allowed one vote per client, a representative of which sat on the P&T committee. Several of the meetings began each discussion of a new drug with a question as to whether any committee member should be excused from that vote or discussion due to financial interest in the manufacturer of that drug. A pharmacist or team of pharmacists gave the presentation of information about the new drugs under consideration. These presentations were brief, the details having been supplied to the members prior to the meeting, including formulary recommendations, and were followed by discussion from the group in general. The discussions were very interactive, with many questions and dissenting points of view. In every meeting observed, at least one recommendation made by the presenting pharmacist s ; was not accepted and prozac. Assistance strongly supports each state's effort to assure that clients receive their prescription drugs. In many cases we would be unable to resolve client problems without CMS's help. TBME-00690-2005.R2 system SRS ; . The topics covered in this report include: 1 ; proportion of total current diverted through the implanted conductor; 2 ; effect of size and shape of electrodes on nerve activation thresholds; 3 ; effect of skin type and thickness on stimulus thresholds; 4 ; effect of misalignment of surface and pick-up electrodes; 5 ; graded control of muscle force; 6 ; changes in muscle contraction thresholds and maximal forces over time in chronic implants; 7 ; mechanism of charge transfer from the skin electrodes to the nerve via the implanted conductor. II. METHODS As we were studying a completely new way of delivering stimulation to nerves, our study was exploratory in nature. To characterize the electrical and functional properties of the SRS across a variety of skin types, acute non-recovery experiments were performed in four cats, four rabbits and a Duroc piglet. In addition, passive conductors were implanted chronically in three cats and their operation as part of an SRS was monitored for several months. All experiments were performed with the approval of the University of Alberta Health Sciences Animal Policy and Welfare Committee. The human perceptual threshold measurements were carried out under a protocol approved by the University of Alberta Health Research Ethics Board. SRS designs: External stimulators, surface electrodes and nerve cuffs are conventional components of the SRS that have been widely discussed in the literature [8]. The novel component of the SRS is the subcutaneous terminal that "picks up" some of the current flowing between a pair of surface electrodes and delivers it through an insulated wire to a nerve. In our study, we used conventional external components and nerve cuffs and explored various shapes and sizes of pick-up terminal. Surface electrodes: these consisted of pairs of self-adhesive conductive gel surface electrodes, 34 mm x 23 with a 10 mm diameter central terminal Kendall Soft-E; The Kendall Company, Mansfield, Massachusetts ; affixed to the closelyshaved skin, well away from the target nerve and muscle, usually on the back . The anodal surface electrode was typically placed on the skin 30 to 50 away from the cathodal surface electrode. Implanted conductors: In acute experiments, the pick-up terminals included discs or rectangles of stainless steel or bared lengths of Cooner AS814 lead wire coiled tightly around 2 0 prolene suture thread Ethicon, Inc., Somerville New Jersey ; , similar to the termination of the "Peterson" electrode [16]. In chronic experiments, only stainless steel discs were used. Dimensions are given in Results. In all cases, delivery terminals nerve cuffs ; consisted of an 8 x10 mm piece of stainless-steel mesh 8 counts mm: Stainless Mesh; Continental Wire Cloth Corp., Edmonton, Alberta ; within a 12 mm long, longitudinally slit silastic tube 3.4 mm inside diameter, 4.7 mm outside diameter; Dow Corning Corp., MI ; . In acute experiments, pick-up terminals were. In the first collaboration by competing aids drug makers, bristol-myers squibb co and gilead sciences inc formed a joint venture to test and market a single pill combining three widely used medicines. It has anti-static properties suitable for clean room and critical environment applications.
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