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A PROCESS FOR PREPARING A PHARMACEUTICAL COMPOUND : C07D 209 14, A61K 31 454 60 US PCT US02 39883 12 WO NIL N.A. NIL N.A. 71 ; Name of Applicant: WYETH Address of the Applicant: FIVE GIRALDA FARMS, MADISON NJ 079400784 USA.
MDMA administration and that it is not restricted to the loci where degeneration might be expected i.e. the 5-HT containing cells of the Raphe nucleus ; . 40. Kish SJ: How strong is the evidence that brain serotonin neurons are damaged in human users of ecstasy? Pharmacol Biochem Behav 2002, 71: 845-855. Ricaurte GA, Yuan J, Hatzidimitriou G, Cord BJ, McCann UD: Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA `ecstasy' ; . Science 2002, 297: 2260-2263. Sumnall HR, Jerome L, Doblin R, Mithoefer MC: Response to: Parrott AC, Buchanan T, Heffernan TM, Scholey A, Ling J, Rodgers J 2003 ; Parkinson's disorder, psychomotor problems and dopaminergic neurotoxicity in recreational ecstasy MDMA users. Psychopharmacology 167: 449-450. Psychopharmacology Berl ; 2004, 171: 229-230. Ricaurte GA, Yuan J, Hatzidimitriou G, Cord BJ, McCann UD: Response to O'Shea and Colado: the MDMA neurotoxicity profile might provide clues to mechanisms. Trends Pharmacol Sci 2003, 24: 275. Parrott AC, Rodgers J, Buchanan T, Scholey AB, Heffernan T, Ling J: The reality of psychomotor problems, and the possibility of Parkinson's disorder, in some recreational ecstasy MDMA users: a rejoinder to Sumnall et al. 2003 ; . Psychopharmacology Berl ; 2004, 171: 231-233. Chung KK, Dawson VL, Dawson TM: New insights into Parkinson's disease. J Neurol 2003, 250 Suppl 3 ; : III15-III24. 46. Damier P, Hirsch EC, Agid Y, Graybiel AM: The substantia nigra of the human brain. II. Patterns of loss of dopaminecontaining neurons in Parkinson's disease. Brain 1999, 122: 1437-1448. Ricaurte GA, Yuan J, Hatzidimitriou G, Cord BJ, McCann UD: Retraction. Science 2003, 301: 1479. This is the retraction of the paper cited above as [41]. The retraction was necessitated by the discovery that the drugs supplied to Ricaurte and colleagues had been incorrectly labelled by the suppliers, and that the drug used as MDMA was in fact methamphetamine. 48. Fornai F, Lenzi P, Frenzilli G, Gesi M, Ferrucci M, Lazzeri G, Biagioni F, Nigro M, Falleni A, Giusiani M et al.: DNA damage and ubiquitinated neuronal inclusions in the substantia nigra and striatum of mice following MDMA ecstasy ; . Psychopharmacology Berl ; 2004, 173: 353-363. Kanthasamy A, Sprague JE, Shotwell JR, Nichols DE: Unilateral infusion of a dopamine transporter antisense into the substantia nigra protects against MDMA-induced serotonergic deficits in the ipsilateral striatum. Neuroscience 2002, 114: 917-924. Buchert R, Thomasius R, Nebeling B, Petersen K, Obrocki J, Jenicke L, Wilke F, Wartberg L, Zapletalova P, Clausen M: Long-term effects of `ecstasy' use on serotonin transporters of the brain investigated by PET. J Nucl Med 2003, 44: 375-384. Buchert R, Thomasius R, Wilke F, Petersen K, Nebeling B, Obrocki J, Schulze O, Schmidt U, Clausen M: A voxel-based PET investigation of the long-term effects of `ecstasy' consumption on brain serotonin transporters. J Psychiatry 2004, 161: 1181-1189. Schmidt WJ, Mayerhofer A, Meyer A, Kovar KA: Ecstasy counteracts catalepsy in rats, an anti-parkinsonian effect? Neurosci Lett 2002, 330: 251-254. Lamers CT, Ramaekers JG, Muntjewerff ND, Sikkema KL, Samyn N, Read NL, Brookhuis KA, Riedel WJ: Dissociable effects of a single dose of ecstasy MDMA ; on psychomotor skills and attentional performance. J Psychopharmacol 2003, 17: 379-387. Iravani MM, Jackson MJ, Kuoppamaki M, Smith LA, Jenner P: 3, 4-methylenedioxymethamphetamine ecstasy ; inhibits dyskinesia expression and normalizes motor activity in 1methyl-4-phenyl-1, 2, 3, primates. J Neurosci 2003, 23: 9107-9115. Current Opinion in Pharmacology 2005, 5: 7986.
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