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NUTRITION The government's new food pyramid emphasizes exercise for the first time; Walter Willet, M.D., professor of epidemiology & nutrition at Harvard criticized it as ".a huge lost opportunity to convey information about healthy food choices that could benefit Americans enormously." His concerns: 1 ; excess emphasis on dairy 2 ; failure to stress importance of replacing transfats & saturated fats with unsaturated fats. JAMA 6 1 05 p2581 In a 200, 000 person study, an undetermined processed meat additive, ?sodium nitrite ; increased pancreatic cancer risk 67-fold in those consuming large amounts. Mtg Amer Assoc Can Research, LE Daily News 4 26 05 study in patients averaging 70 years of age, 36% consumed more than 65gm of fat daily 65gm about 30% of daily calories the rate of stroke from clots in this group was 60% higher. FPN 3 15 05 high sodium diet substantially reduces calcium absorption. AJCN 4 05 p845. Higher omega-3 fatty acids e.g. fish oil ; relative to omega-6 fatty acids is associated with higher bone mineral density at the hip. AJCN 4 05 p934. Isoflavones, which derive from legumes, primarily soy, may reduce bone loss in younger post-menopausal women; in Asian populations, isoflavones are associated with.
Antioxidant properties have been reported for isoflavones both in vitro and in vivo. Equol, in model membrane systems, was a more effective antioxidant than genistein or the parent compound daidzein [37], and shows structural similarity to the tocopherols [7]. Furthermore, soya isoflavone consumption 56 mg\day for 17 days ; has been reported to decrease plasma isoprostane biomarker for lipid peroxidation ; concentrations [38]. Antioxidant action could contribute to anticancer ability because reactive oxygen species could initiate signal transduction through the mitogenactivated protein ` MAP ' ; kinases [7]. The antioxidant action of phytoestrogens may contribute also to their cardioprotective properties. Isoflavones can protect low-density lipoprotein LDL ; against oxidative modification in vitro [37]. Furthermore, in a recent study, resistance of LDL to oxidation showed a significant increase following the high isoflavone dietary treatment [38]. These observations suggest that soya isoflavones may protect against the oxidative damage implicated in atherosclerosis and cardiovascular disease generally [38]. Genistein may enhance the action of TGF [31, 39]. This action may be a link between the effects of genistein in a variety of chronic diseases, including atherosclerosis and hereditary haemorrhagic telangiectasia HHT ; the OslerWeber Rendu syndrome ; , in which defects in TGF signalling have been characterized [40, 41]. Indeed, pilot studies have shown that genistein consumption significantly alleviated symptoms in patients with HHT [41]. However, many flavonoids, such as the flavonol quercetin and also the isoflavone genistein, have been shown to inhibit the action of enzymes such as sulphotransferases important for inactivating the endogenous oestrogens implicated in breast cancer [42], suggesting that further human studies to gain a complete picture of all the biological actions of isoflavones in vivo are clearly required.
Thus, during pregnancy in humans, isoflavones per se could be a risk factor for abnormal brain and reproductive tract development.
Scambia et al. 2000 ; and the other one where almost one third of the subjects discontinued the trial Faure et al. 2002 ; Table 14A ; . The inconsistency of the data has been explained by the presence of soy protein soy diet ; or its lack isolated isoflavonoids ; , although the clinical effects seem to be of the same magnitude with Table 14B ; or without Table 14A ; soy protein. The initial and very promising data were often obtained from trials using no placebo control, which casts doubts on the specificity of the claimed benefit. The use of isoflavonoids had no objective beneficial effect on vaginal dryness in our subjects. This is not in line with the results of some other studies suggesting that soy isoflavones 100118 mg day ; Kotsopoulos et al. 2000, Han et al. 2002 ; alleviated vaginal dryness. It should also be noted that isoflavonoids have had no effect on vaginal epithelium in most previous studies Albertazzi et al. 1999, Baber et al. 1999, Duncan et al. 1999, Scambia et al. 2000, Upmalis et al. 2000 ; , although the data are not uniform Wilcox et al. 1990, Baird et al. 1995, Dalais et al. 1998 ; . Moreover, our isoflavonoid regimen was not accompanied by any estrogenic effects in the endometrium, which we investigated with the aid of ultrasonography, histology and the expressions of markers reflecting endometrial reactivity to various steroid hormones. It was known before that isoflavonoid supplements 40132 mg day ; for 36 months do not affect endometrial thickness or histology Baber et al. 1999, Duncan et al. 1999, Scambia et al. 2000, Upmalis et al. 2000, Balk et al. 2002, Penotti et al. 2003 ; , but the effects of isoflavonoids on expression of ER and PR in human endometrium had never been studied before. After the start of our trial it was reported that red cloverderived isoflavones 50 mg day ; do not affect the expression of endometrial Ki-67 in perimenopausal women Hale et al. 2001 ; . We can now expand this knowledge to concern postmenopausal women, whose endometrium remained totally unaffected by isoflavonoid supplementation. Bone mineral density not to mention incidence of fractures ; takes years to show any changes in response to any treatment. Hence, various markers reflecting bone resorption and formation are most often used to assess the effects of a given compound on bone, and they respond to various treatments well in three to six months Delmas 2000 ; . Isoflavonoid treatment was found to reduce the output of bone resorption markers in our study. However, this response was not so marked as reported in some other trials involving genistein; 54 mg day was claimed to decrease Pyr output by 54% and Dpyr output by 55% in six months Morabito et al. 2002 ; . It has also been reported that whole soy foods containing isoflavones 60 mg day ; cause a fall of 14% in NTx levels in three months Scheiber et al. 2001 ; . However, in some other trials, isoflavones 4782 mg day ; have led to no changes in NTx 55.
7. Any additional matters relating to the usage of safe passage will be coordinated through the JSC. 3. Passage and Mode of Transit 1. Persons and vehicles in transit under these arrangements shall neither break their journey nor depart from the designated routes, and shall complete the transit within the designated time stamped on their safe passage cards and permits, unless a delay is caused by a medical emergency or a technical breakdown.
Preservation of airway reflexes. Its primary disadvantage is emergence reactions The typical total dosages of medication vary considerably among patients but do correlate with the procedure duration. Recovery is typically rapid 10 min ; with a minimum amount of delirium and confusion. The most common complications are nausea and vomiting, which fortunately occurs in a minority of patients. Discharge times are longer for patients who develop nausea and vomiting, younger patients, and patients receiving preoperative oral sedation. Most moderate and deep sedation techniques involve the following steps: 1. Establish an intravenous line. 2. Administer fentanyl 0.05 to 1 g prn and 3. Administer midazolam 0.5 to 1 mg IV prn and or 4. Administer continuous propofol infusion 25 to 50 min ; , increasing at increments of 5 m min prn. Rarely more than 100 g kg min is needed. All medications should be carefully titrated in order to achieve the desired level of sedation. The typical total dosages of medication correlate significantly with procedure duration as well as patient age, sex, and weight. A designated individual should be present to monitor the patient throughout the procedure. This individual should be able to recognize all complications associated with sedation, understand the pharmacology of the agents that are administered, and understand the role of pharmacologic antagonists for opioids and benzodiazepines. In addition, at least one individual with advanced life-support skills should be immediately available and isoniazid.
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Soybean isoflavone as health care food has been listed as one of the best 10 investment projects in the world and vasodilan.
It has been reported that many bifidobacteria17 and some other lactic acid bacteria3, 14 hydrolyze isoflavone glycosides into corresponding aglycones. In general, isoflavones express higher biological activity such as estrogenlike activity in the aglycone form, since aglycone isomers are able to bind to hydrophobic sites of receptors or enzyme proteins16. Thus, it is expected that the biological activity of soybean milk increases after fermentation using the strains which could hydrolyze isoflavone glycosides. From these results, it is concluded that the most suitable strains to produce the yogurt-like fermented soybean milk containing high concentrations of isoflavone agly.
Treatment Outcomes Sharon Reif, M.A. Presented by: Sharon Reif, M.A., Research Associate, Schneider Institute for Health Policy, Heller School, Brandeis University, 415 South Street, MS035, Waltham, MA 02454; Tel: 781 ; 736-3924; Fax: 781 ; 736-3928; E-mail: reif brandeis Research Objective: 1 ; To determine if wraparound services received during substance abuse treatment affect the probability of abstinence since discharge. 2 ; To determine if a ratio of services received to services needed affects the probability of abstinence since discharge. Study Design: Secondary data analysis of the Alcohol and Drug Services Study, which is a large, nationally representative sample of treatment facilities and their clients, funded by SAMHSA. Logistic regression is used to predict the probability of abstinence; independent variables consist of facility and client characteristics, and treatment and wraparound services. Wraparound services include employment counseling, academic education, medical care, housing assistance, financial counseling, legal counseling, prenatal care, HIV AIDS education, and psychological testing. Objective 1 is tested by identifying clients with a specific need for a service, and comparing the results of the regression analyses between those who received the service and those who did not; the first group is also compared to clients with no need for a service. Objective 2 relies on a created ratio of the number of services needed and received to the number of services needed; this ratio is included in the regression analysis, as a specific predictor of abstinence. Need for a service is determined retroactively, based on existing data. Population Studied: Clients discharged from a sampled episode of outpatient non-methadone treatment, and who participated in the follow-up interview, an average of one year after discharge. The sample consists of 899 clients from 143 treatment facilities. Data was collected from 1997-2000 and ketorolac.
Patients scheduled awards include biological health psychosis.
Very interesting new study about the soy isoflavones and phytoestrogens genistein, daidzein and equol and ketotifen.
Reduction and containment measures of their own. It is not possible to predict the extent to which we or the healthcare industry in general might be affected by these changes. Continuing reviews of the utilization, safety and efficacy of healthcare products and their components are being conducted by industry, government agencies and others. These studies, which employ increasingly sophisticated methods and techniques, can call into question the utilization, safety and efficacy of previously marketed products and in some cases have resulted, and may in the future result, in the discontinuance of such products and give rise to claims for damages from persons who believe they have been injured as a result of their use. Similar consequences can arise as a result of adverse events, which can impact both innovator and generic versions of the same drug. We maintain product liability insurance for such potential claims; however, no such claims have ever been asserted against us. Other Regulations We believe that we comply with environmental laws that apply to us and we do not anticipate that continuing compliance will have a material effect on our financial condition or results of operations. Item 2. Properties.
Botulinum A toxin is a useful addition to the armentarium for the overactive bladder, especially where anticholinergic drugs are ineffective. FC and lamictal.
Q: What would you do to implement a reduction in ADRs? The basis for most ADRs are: 1 ; variability between individuals in terms of the pharmacokinetics or pharmacodynamics of a drug ; 2 ; drug-drug interactions. Many of the former will be predictable in the future or are now ; based on an individual patient's genotype e.g. for P450 polymorphisms ; . However, drug-drug interactions are the single most important and readily preventable ; cause of ADRs. Hence, strategies for reducing ADRs must set about reducing drug interactions e.g. Educate Prescribers at all levels about interactions and the particular risk of polypharmacy Monitoring of prescription events e.g. by Ward based pharmacists Use of electronic prescription to prevent highlight prescriptions that would cause interactions, for example, soy isoflavones 40.
Joshi, C.P., and Chiang, V.L. 1998 ; . Conserved sequence motifs in plant S-adenosyl-L-methioninedependent methyltransferases. Plant Mol. Biol. 37, 663674. Jung, W., Yu, O., Lau, S.-M.C., O'Keefe, D.P., Odell, J., Fader, G., and McGonigle, B. 2000 ; . Identification and expression of isoflavone synthase, the key enzyme for biosynthesis of isoflavones in legumes. Nat. Biotechnol. 18, 208212. Kessmann, H., Choudhary, A.D., and Dixon, R.A. 1990 ; . Stress responses in alfalfa Medicago sativa L. ; . III. Induction of medicarpin and cytochrome P450 enzyme activities in elicitor-treated cell suspension cultures and protoplasts. Plant Cell Rep. 9, 3841. Kochs, G., and Grisebach, H. 1986 ; . Enzymic synthesis of isoflavones. Eur. J. Biochem. 155, 311318. Kosslak, R.M., Bookland, R., Barkei, J., Paaren, H.E., and Applebaum, E.R. 1987 ; . Induction of Bradyrhizobium japonicum common nod genes by isoflavones isolated from Glycine max. Proc. Natl. Acad. Sci. USA 84, 74287432. c Ku , J. 1995 ; . Phytoalexins, stress metabolism, and disease resistance in plants. Annu. Rev. Phytopathol. 33, 275297. Lamb, C.J., Ryals, J.A., Ward, E.R., and Dixon, R.A. 1992 ; . Emerging strategies for enhancing crop resistance to microbial pathogens. Bio Technology 10, 14361445. Lee, H.P., Gourley, L., Duffy, S.W., Esteve, J., Lee, J., and Day, N.E. 1991 ; . Dietary effects on breast-cancer risk in Singapore. Lancet 337, 11971200. Li, L., Popko, J.L., Zhang, X.-H., Osakabe, K., Tsai, C.-J., Joshi, C.P., and Chiang, V.L. 1997 ; . A novel multifunctional O-methyltransferase implicated in a dual methylation pathway associated with lignin biosynthesis in loblolly pine. Proc. Natl. Acad. Sci. USA 94, 54615466. Li, L., Popko, J.L., Umezawa, T., and Chiang, V.L. 2000 ; . 5-Hydroxyconiferyl aldehyde modulates enzymatic methylation for syringyl monolignol formation, a new view of monolignol biosynthesis in angiosperms. J. Biol. Chem. 275, 65376545. Matzke, M.A., and Matzke, A.J.M. 1995 ; . How and why do plants inactivate homologous trans ; genes? Plant Physiol. 107, 679685. McKhann, H.I., and Hirsch, A.M. 1994 ; . Isolation of chalcone synthase and chalcone isomerase cDNAs from alfalfa Medicago sativa L. ; : Highest transcript levels occur in young roots and root tips. Plant Mol. Biol. 24, 767777. Paiva, N.L., Edwards, R., Sun, Y., Hrazdina, G., and Dixon, R.A. 1991 ; . Stress responses in alfalfa Medicago sativa L. ; . XI. Molecular cloning and expression of alfalfa isoflavone reductase, a key enzyme of isoflavonoid phytoalexin biosynthesis. Plant Mol. Biol. 17, 653667. Paiva, N.L., Oommen, A., Harrison, M.J., and Dixon, R.A. 1994 ; . Regulation of isoflavonoid metabolism in alfalfa. Plant Cell Tissue Organ Cult. 38, 213220. Restrepo, M.A., Freed, D.D., and Carrington, J.C. 1990 ; . Nuclear transport of plant potyviral proteins. Plant Cell 2, 987998. Sambrook, J., Fritsch, E.F., and Maniatis, T. 1989 ; . Molecular cloning. In Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press ; . Shorrosh, B.S., Dixon, R.A., and Ohlrogge, J.B. 1994 ; . Molecular cloning, characterization and elicitation of acetyl CoA carboxylase from alfalfa. Proc. Natl. Acad. Sci. USA 91, 43234327 and lamotrigine.
Preferably the isoglavone is selected from genistein, genistin, 6 -o-malonylgenistin, 6 -o-acetylgenistin, glycitein, glycitin, 6 -o-malonylglycitin, biochanin a, or mixtures thereof.
Anti-parallel fashion and every a pair of them exists fourC H hydrogen bonds, C 14 ; H 14 ; Cg1 * , C 15 ; H Cg2 * , C 14 * ; H Cg1 and C 15 * ; H Cg2, where Cg1 and Cg2 are the centre of gravity of the ring A and ring C of isoflavone, respectively Figure 6 ; . The adjacent pairs of 9soflavone and levothyroxine.
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Soy Consumption of Taiwanese Children in Taipei. K. Hsiao * and P. Lyons-Wall. * National Taiwan Normal University, Chung-Shan Medical University, Taiwan ROC; Queensland University of Technology, Australia. Soybeans have been a staple food in the traditional Asian cuisine for many centuries. Recent experimental evidence has shown that soy consumption could be a contributing factor to the low rates of heart disease and cancer observed in Asian communities, yet controversy remains as to whether eating soy is beneficial for children--mainly because of the presence in soy of the weakly estrogenic isoflavones. This study examined the range and frequency of intake of soy foods in Taiwanese children in Taipei aged 8 9 y. Total isoflavone intakes were estimated by using a food frequency questionnaire and compared with selected demographic variables. Children consumed a diversity of soy products 20 different items ; reflecting the use of soy as a traditional staple food in the Taiwanese cuisine. The most commonly consumed items were soymilk, with a mean intake of 655 g wk, soft tofu 207 g wk ; , and firm tofu 120 g wk ; . associations were found between isoflavone intakes and demographic characteristics such as age, body mass index, and family income. The average daily intake of isoflavones in this study 39 mg d ; is comparable with intakes that have resulted in physiological effects in young women. However, no effects have been reported in children, either anecdotally or in the scientific literature. The potential estrogenic effects of isoflavones may be lowered in children because of the first-pass effect in the liver or the tissues of children may be less sensitive to the effects of isoflavones than tissues of adults. Using Web-Based Computer Nutrition Education to Effect Attitude Toward Soy Products in an Elderly Population. J. Painter * and J. North. * Eastern Illinois University, IL; Univeristy of Illinois Urbana-Champaign, IL. Soy was introduced into the human diet in China over 4000 y ago. Soy has only recently been introduced into the American diet and many find the beany flavor of soy objectionable. The problem of off-flavors in soy protein products has been a major limitation for its use and was a major topic of discussion at the first World Soy Protein Conference in 1973 and the World Conference on Vegetable Food Proteins in 1978. The perception that soy foods do not taste good is still a problem today. This study and lithium and isoflavone.
Food Beans Bean sprouts, alfalfa Bread, brown, white cereals i.e. wheat bran, cornflour, maize, oatmeal Fruit i.e. apples, banana, oranges, etc. 0.1d 0.1b a Legumes 0-0.58 Linseeds flaxseed ; 60-370b b a Nuts, i.e. peanuts, hazel nuts, etc. 0.1 0 0.02-0.33b a a Peas, i.e. lentil and split 0.1-2.5 0 0-0.20b a e Seeds i.e. sunflower, alfalfa, clover 0.01-0.6 72-561 Soy milk 5-10a Soy sauces 0.1-1.6a 0.03b a a Soy flour 131-198 0 0.13a a a Soy beans 14-153 0.05 0.01-0.27b a a Teas i.e. black, green 0.04-0.05 0 2.04b a Tempeh 29-53 Tofu 13.5-67a Adapted from: aUSDA-Iowa State University isoflavones database 2002 bMazur et al. 1998 cLiggins et al. 2002 dLiggins et al. 2000 eFranke et al. 1995 signifies not determined Isoflavones mg 100 g 0-1.5a 0-0.8c 0.1d Coumestrol mg 100 g 0-3.6a 4.7a 0 Lignans mg 100 g 0.05-0.18b 0.5b.
The final result: using the kupperman index to quantify menopausal symptoms, the group taking the isoflavone experienced measurable decreases in almost all symptoms, including hot flashes, mood swings, insomnia, headaches and palpitations and loxitane.
Impaired mental ability during oestrus when hormone levels were low compared to proestrus when hormone levels were at their highest. As vaginal smears were not taken throughout the experiment it is unclear if the rats were displaying normal oestrous cycles, or if this small amount of phytoestrogen had been strong enough to block the LH surge. These previous findings do not support the results that were found in this study. Comparison of oestrus and proestrus performance in the open field arena was not significant P 0.05 ; P 0.778. Changes in body weight during the study may have been a result of the oestrous cycle. During oestrus the body weight is expected to be the lowest due to the increase in activities such as wheel running and a decrease in food consumption Lewis et al., 2003 ; . However, our rats were still growing so we expected them to still gain weight, although the rate of gain may decrease during oestrus. This decrease in food consumption and therefore isoflavones may explain the lower level of performance that was seen during this stage of the cycle.
Effects have been observed with anthocyanin biosynthesis by Daucus carota cells at 30C Narayan et al., 2005 ; . These results may lead to the possibility of using this parameter as a tool for manipulation of isoflavone production by in vitro.
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39. Genazzani AR, Petraglia F, Facchinetti F, et al. Effects of Org OD 14 on pituitary and peripheral beta-endorphin in castrated rats and postmenopausal women. Maturitas 1987; Suppl 1: 35-48. 40. Castlo-Branco C, Vicente J, Figueras F, et al. Comparative effects of estrogens plus androgens and tibolone on bone, lipid pattern and sexuality in postmenopausal women. Maturitas 2000; 34: 161-168. Gompel A, Kandouz M, Siromachkova M, et al. The effects of tibolone on proliferation, differentiation and apoptosis in human breast cells. Gynecol Endocrinol 1997; 11 Suppl 11: 79. 42. Hammar M, Christau S, Nathorst-Boos J, et al. A double blind randomised trial comparing the effects of tibolone and continuous combined hormone replacement therapy in postmenopausal women with menopausal symptoms. Br J Obstet Gynaecol 1998; 105: 904-911. Valdivia I, Ortega D. Mammographic density in postmenopausal women treated with tibolone, estriol or conventional hormone replacement therapy. Clin Drug Invest 2000; 20: 101-107. Winkler U, Altkemper R, Kwee B, et al. Effects of tibolone and continuous combined hormone replacement therapy on parameters in the clotting cascades: a multicenter, double blind randomized study. Fertil Steril 2000; 74: 10-19. IBIS Investigators. First results from the international breast cancer intervention study IBIS-I ; : a randomised prevention trial. Lancet 2002; 360: 817-824. Yaffe K, Krueger K, Sarkar S, et al. Cognitive function in postmenopausal women treated with raloxifene. N Engl J Med 2001; 344: 1207-1213. Lippman M, Krueger K, Eckert S, et al. Indicators of lifetime oestrogen exposure: effect on breast cancer incidence and interaction with raloxifene therapy in the multiple outcomes of raloxifene evaluation study participants. J Clin Oncol 2001; 19: 3111-3116. Barrett-Connor E, Grady D, Sashegyi A, et al. Raloxifene and cardiovascular events in osteoporotic postmenopausal women: 4-year results from the MORE Multiple Outcomes of Raloxifene Evaluation ; Randomized Trial. JAMA 2002; 287: 847-857. Shang Y, Brown M. Molecular determinants for the specificity of SERMs. Science 2002; 295: 2465-2468. Davis S, O'Neill S, Eden JA, et al. Transition from estrogen replacement therapy to raloxifene in early postmenopausal women [abstract]. Proceedings of the North American Menopause Society; 2002 Oct 3-5; Chicago, Ill: 107, P-131. 51. Hale G, Hughes CL, Kline G. Endometrial cancer: hormonal factors, the perimenopausal "window of risk, " and isoflavones. J Clin Endocrinol Metab 2002; 87: 3-15. Lasley B, Santoro N, Randolf J, et al. The relationship of circulating dehydroepiandrosterone, testosterone and estradiol to stages of the menopausal transition and ethnicity. J Clin Endocrinol Metab 2002; 87: 3760-3767. Goldstat R, Briganti E, Tran J, et al. Transdermal testosterone improves mood, well being and sexual function in premenopausal women. Menopause 2003. In press. Received 22 Oct 2002, accepted 24 Mar 2003.
Recent changes to the national cholesterol education program guidelines, which broadened the patient population for cholesterol control medicines, suggest a three-fold increase in the untreated and treatment-eligible patient population in the united states, from 13 million to 40 million and isoniazid.
A survey of entries 113 in Table 1 reveals that of all the types of CC coupling that we have attempted, the MiyauraSuzuki reaction is the cleanest and generally gives the best yields of coupled product. Coincidently, as part of one of our structureactivity relationship studies, we required a quantity of substituted bicyclic compounds of the isoflavone class Eq. 1; e.g., 7a7d ; . These derivatives therefore presented us with a good series of candidates for our investigations of coupling chemistry using 1. Isoflavones represent a very important class of natural products26 because they display a wide variety of biological properties that include anti-cancer, anti-oxidant, antiinflammatory, anti-bacterial and anti-fertility activity. In addition, isoflavones have been shown to act as selective enzyme inhibitors5bf, 26, to alleviate erectile dysfunction27 and have been investigated as medicinal agents for the.
Source: Jenkins, D., Kendall, C., Jackson, C., Connelly, P., Parker, T., Faulkner, D., Vidgen, E., Cunnane, S., Leiter, L., & Josse, R., Effects of high-and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocystein, and blood pressure in hyperlipidemic men and women. J Clin Nutr 2002; 76: 365-72.
Peggy cawthon of california pacific medical center in san francisco and colleagues note.
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