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The study population consisted of 33 patients aged between 18 and 65 years, with stage 1 essential hypertension. Eighteen patients were assigned to group B + A men, 55 2 years ; while 15 were assigned to group B 10 men, 49 2 years ; , both following a randomized and double-blind procedure. Patients with a clinical or laboratory suspicion of secondary hypertension were excluded, as were patients with refractory hypertension, diabetes, coronary disease, cardiomyopathy, valve disease, severe vascular disease, organ failure, known intolerance to any of the study drugs, illegal drug abuse, women of child-bearing age who expressed their desire to get pregnant or who were not using safe contraceptive methods, women who were breastfeeding and patients who were on antihypertensive medication, who for whichever reason, could not discontinue such medications so as to enter the washout period. The study protocol was approved by the Education and Research Committee, as well as the Institutional Ethics Committee. Before inclusion in the study, each patient signed the consent for voluntary participation. From that moment on, patients who were receiving antihypertensive medication, discontinued the drugs. During the four weeks prior to the beginning of the active phase of the study, all patients received a tablet of placebo. All patients were instructed to follow a low-sodium diet and continue with the same lifestyle throughout the duration of the study. Patients were encouraged to stop smoking, only when appropriate. After that phase, patients with systolic BP SBP ; and or diastolic BP DBP ; between 140179 90-109 mm Hg were included. Blood pressures were measured with a mercury sphygmomanometer, following the guidelines recommended by the World Hypertension League. 16 ; In each subject, the BP value recorded was the average of three measurements performed in each of the three consecutive visits, before patient randomization. Each patient included received a tablet of benazepril + amlodipine 10 5 mg, or benazepril 10 mg, according to the randomization. At 4 weeks, if BP was 140 90 mm Hg the office, the dose of B + was increased to 20 5 mg or the dose of B was increased to 20 mg. If after an additional 4 week period, BP was 160 100 mm Hg, the patient was withdrawn from the study. All patients attended one medical visit per month, which included BP measurement, assessment of symptoms and probable adverse effects due to the treatment. Laboratory tests consisted of complete blood cell count, liver function tests, glycemia, uremia, serum creatinine and ions, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, uricemia, urinary sediment, 24-hour proteinuria and ABPM, and were performed at the beginning of treatment and at 3 and 6 months. All laboratory tests were performed at the Institution's Laboratory. 24-hour Blood pressure monitoring ABPM ; : it was performed with a Spacelab 90207 30 equipment, properly calibrated. The monitor was programmed to perform readings every 15 minutes during the wake period 07: 00-22: 00 h ; and every 20 minutes during nocturnal rest 22: 00-07: 00 h ; . Night and day periods were adjusted according to the patient's diary. Any recording without at least 80% of the readings and one reading per hour was discarded. The averages of SBP DBP and heart rate HR ; were recorded. Addi tionally, pulse pressure PP SBP-DBP ; and mean blood pressure MBP [PP 3] + DBP ; were calculated for 24 hours and for the diurnal and nocturnal periods!

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ROSS L. GAULD, A. S. SCHLINGMAN, ELIZABETH B. JACKSON, MARY C. MANNING, HERBERT C. BATSON, AND CHARLOTTE C. CAMPBELL Army Medical Department Research and Graduate School, Washington, D. C., and Research Laboratories, Parke, Davis and Company, Detroit, Michigan.

1. CME Cycle Starting from 1 January 2005, the commencement date of CME cycle of all Fellows will be synchronized upon the Medical Council of Hong Kong proposed implementation of CME CPD for all registered medical practitioners from 2005. All Fellows will be informed about their own required CME points for the current cycle till.
Indicated by a tall, peaked "uncomfortable-to-sit-on" p wave in lead ii; 3 ; incomplete right bundle branch block or rsr' pattern in lead v1 4 ; low voltage; 5 ; persistent precordial s waves; 6 ; "strain" in right ventricular leads inferior or anterior precordial leads and 7 ; tall r wave in lead v1.

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